Mexico City delivers at every level. Its indie design boutiques,  Art Deco palaces, ever-evolving culinary scene—both street food and high-end—and art museums are unmatched. Spend an afternoon in the bohemian neighborhood of Coyoacán, exploring Frida Kahlo’s home and browsing crafts and ceramics at the local market. Then settle into a cafe for a horchata or mezcal with nowhere to be.